An additional meta-GWAS study reported that a Netrin-1 SNP, rs8081460, was associated with neuroticism (which is highly genetically correlated with depression) in the UK Biobank sample (n = 91,370), although this SNP effect did not replicate in two smaller, independent samples (n = 6659 and n = 8687) [75]. This evidence concerns the gene NTN1 and major depressive disorder.