Although IMQ-induced psoriasis recapitulates limited aspects of human psoriasis and is highly dependent on a prevalent population of dermal γδ T cells, which is a minor population in human skin30, the activation of TLR7/8 in human dendritic cells was reported to contribute to psoriasis31, and TLR7/8/9 antagonists reduced moderate-to-severe plaque psoriasis in a phase IIa trial32. Here, TLR7 is linked to psoriasis.