To further identify other host-targeted therapeutics against intracellular MRSA, we interrogated our shRNA screening results to identify four genes, i.e. CD83, FAM63B, MYL2 and TRAM2, whose silencing in HeLa cells resulted in a significant reduction of intracellular S. aureus survival while host cell viability was enhanced after cell infection. The gene discussed is CD83; the disease is infection.