However, these results and evidences should be tested further and confirmed in vivo in the own malaria parasite where complexity increases substantially and the actual conditions could differ (e.g. H2O2 concentrations in digestive vacuole, specific cysteine proteases involved, antioxidant mechanisms, among many other factors), and these changes might affect quinoline-heme interactions as well as peroxidative actions and inhibition of proteolysis. The gene discussed is CTSB; the disease is malaria.