To further confirm the effects of LMP1 expression on SMG1 expression and mTOR activation in NPC cells, LMP1 was expressed in 5-8F and 6-10B cells by transfection of pcDNA3.1-LMP1 plasmid and inhibited in C666-1 cells by siRNA-LMP1 transfection, respectively. This evidence concerns the gene SMG1 and nasopharyngeal carcinoma.