PPM1D and colorectal carcinoma: Next, we screened also a cohort of 340 unselected Swedish CRC patients revealing four samples with PPM1D truncating mutation, which included recurrent p.L450* mutation, a deletion affecting c.1632_1636CCCCC homopolymer (c.1636delC; p.L546*), one missense mutation (c.1358C>A; p.S453*) and one insertion (c.1476dupT; p.S493*) outside the homopolymeric regions (Table 1).