Out of the 10 PPM1D mutated CRC samples with wt TP53, all showed high level of MSI and seven carried activating BRAF mutations strongly suggesting that PPM1D mutations clustered into the consensus molecular subtype 1 (CMS1) of CRC characterized by presence of MSI and BRAF mutation56,57. The gene discussed is PPM1D; the disease is colorectal carcinoma.