Moreover, the results of the homeostatic model assessment for insulin resistance (HOMA-IR) showed that from the age of 3 months, the IR index of hIAPP pigs was significantly higher than that of the wild-type pigs, indicating that the hIAPP pigs had reduced insulin sensitivity and increased insulin resistance (P < 0 05, n = 6) (Fig. 5g). Here, INS is linked to Insulin resistance.