If these spontaneous clusters appear to identify “MS-like” and “NMOSD-like” cohorts, we then apply the metabolomics discriminators of MS vs antibody-positive NMOSD (Ab-NMOSD) (obtained by combining AQP4-Ab and MOG-Ab patients) to further validate that these spontaneous clusters are likely to be representing underlying pathologic processes. Here, AQP4 is linked to myeloid sarcoma.