For instance, Sirtuin 3 (SIRT3) protects against mitochondrial damage in sepsis-induced AKI through suppressing the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome, reducing reactive oxygen species (ROS) production, decreasing interleukin-1β (IL1B) and IL18 expression, and weakening oxidative stress [10,11]. Here, SIRT3 is linked to acute kidney injury.