Among them, miR-29b-3p, miR-15b-5p, miR-15a-5p, miR-107, XIST, miR-19a-3p, miR-16-5p, miR-19b-3p, miR-92a-3p, and CUL3 were closely related to the pathogenesis of sepsis-induced AKI. The gene discussed is CUL3; the disease is acute kidney injury.