Cobb et al. [206] identified novel genes associated with MTX response in JIA patients including genes related to TGF beta signaling (ZMIZ1: zinc finger MIZ-type containing 1, TGIF1: TGFB-induced factor homeobox 1) and a member of the multi-drug resistance subfamily of the ATP-binding cassette transporter proteins (CFTR: cystic fibrosis transmembrane conductance regulator). The gene discussed is TGIF1; the disease is juvenile idiopathic arthritis.