The clinical significance of BAFF is found with serum BAFF levels in patients with nonalcoholic steatohepatitis (NASH) patients had higher levels than patients with simple steatosis; meanwhile, the histological findings also demonstrated that higher BAFF levels were associated with the presence of hepatocyte ballooning and advanced fibrosis [13]. This evidence concerns the gene TNFSF13B and metabolic dysfunction-associated steatohepatitis.