INS and fatty liver disease: MB salt is therefore a promising antidiabetic agent as it is able to (1) act as a potent AMPK activator, suppressing gluconeogenesis, (2) prevent hepatic steatosis and reduce the triglyceride (TG) content in hepatocytes, (3) suppress the upregulation of lipogenic and diabetic genes, attenuating lipogenesis, (4) stimulate basal and insulin-stimulated glucose consumption, (5) stimulate glucose metabolism having no insulin, (6) inhibit glucose production and (7) downregulate PEPCK/G6Pase, without cellular toxicity and in a dose-dependent manner [41].