Since FGF21 is elevated in the plasma of T2DM patients and obese individuals, mainly due to FGF21 resistance, the administration of FGF21 analogues seems to be a favorable approach as they probably will lead to an improvement of the lipid profile, reduction of insulin resistance and glucose-lowering, in part due to the increased adiponectin production [46]. Here, ADIPOQ is linked to type 2 diabetes mellitus.