INS and type 2 diabetes mellitus: Taking these results into account, it can be concluded that anti-osteoporotic trace minerals such as Si and Sr, due to their demonstrated lowering effect in glycemia, contribution to improve insulin, leptin, and adiponectin tolerance and lowering glomerulopathy risk through modulation of related pancreatic and renal gene expression, can be regarded as a promising approach to T2DM treatment [72].