BAX and viral infectious disease: The cleavage of Bax at the N-terminal region by calpain, a calcium-dependent cysteine protease [16], has been implicated in several types of stimuli that induce apoptosis in a variety of different cell types, such as drugs or toxic agents [19,32,33,34,35], interferon alpha [36], pollutants [37], and viral infections [38,39].