Curcumin (100 mg/kg twice a day for 50 days intragastrically) contrasted extrapyramidal symptoms and increased HO-1 expression through Akt/Nrf2 phosphorylation in the substantia nigra pars compacta of rats treated with rotenone, a pharmacological tool able to destroy dopaminergic neurons and therefore, used to induce experimental Parkinson’s disease (PD) [71]. This evidence concerns the gene NFE2L2 and Parkinson disease.