CALR and Alzheimer disease: In this regard, Huang et al. [63] tested PLGA-Cur nanoparticles conjugated with S1 peptide (an inhibitor of β-amyloid generation) and calreticulin (CRT) (ligand of transferrin receptor) in both a cellular model of the (BMEC) (brain microvascular endotelial cells) and a transgenic AD mouse model (APP/PS1dE9).