RIGI and infection: The RIG-I-Like Receptor (RLR) pathway has been classically studied for its role in the detection of viral ribonucleic acids and involves Retinoic Acid-Inducible gene I (RIG-I or DDX58), Melanoma Differentiation-Associated protein 5 (MDA5), and Laboratory of Genetics and Physiology 2 (LGP2/DHX58) as cytosolic sensors of an infection.