PTEN and metastatic melanoma: Moreover, several studies are investigating the feasibility and antitumor effect of PI3K-targeting drugs in combination with immunotherapy in patients with metastatic melanoma who lack the PTEN gene (NCT03131908), colorectal cancer (NCT03711058), large B cell lymphoma (NCT03484819), lung cancer (NCT03257722), breast cancer, and gynecologic malignancies (NCT03719326).