On the plasma proteome, three plasma proteins, interleukin-17 receptor C (IL17RC), transmembrane protease serine 4 (TMPRSS4), and copper chaperone for superoxide dismutase (CCS) showed significant concentration differences between MMD patients with and without a RNF213 mutation based on the iTRAQ data (Figure 5A). Here, CCS is linked to multiminicore myopathy.