Absence of maternal imprinting of gene expression in hydatidiform moles has also been observed in the rare biparental hydatidiform moles due to NLRP7 (NLR family pyrin domain containing 7) or KHDC3L (KH domain containing 3 like) mutations, suggesting a common endpoint of pathogenesis [12,14,15]. This evidence concerns the gene NLRP7 and hydatidiform mole.