Absence of maternal imprinting of gene expression in hydatidiform moles has also been observed in the rare biparental hydatidiform moles due to NLRP7 (NLR family pyrin domain containing 7) or KHDC3L (KH domain containing 3 like) mutations, suggesting a common endpoint of pathogenesis [12,14,15]. The gene discussed is KHDC3L; the disease is hydatidiform mole.