This processing is enhanced in cancer cells due to the high demand for continuous ribosome production for their extensive growth.15, 16 In eukaryotes, ribosome biogenesis takes place in the nucleoli that contain genes encoding for ribosomal RNAs (rRNAs), which build the nucleic acid backbone of the ribosome.15 Interestingly, NOP14 siRNA knockdown cells (knockdown confirmation shown in Figure S9) as well as VioA‐treated cells display reduced rRNA levels in nucleoli, as demonstrated by 5‐FU immunostaining (Figure 4 A,B). This evidence concerns the gene NOP14 and cancer.