LEF1 and neoplasm: Another way in which the miR-34 family contributes to tumour suppressive function is that miR-34a, miR-34b*, and miR-34c-5p inhibit the Wnt pathway by repression of Wnt ligand co-receptors (WNT1/3; LRP6), with HMG-box transcription factor (LEF1) and β-catenin.