While prostatic adenocarcinoma lesions presented both with and without goblet cell metaplasia (Fig 7A1 and 7A2 respectively), increased numbers of goblet cells appeared in early invasive tumor lesions (Fig 7B1-1’) and in more extensively invasive lesions with pools of extracellular mucin (Fig 7C1-2’), suggesting an association between the presence of goblet cells and tumor invasiveness and aggressiveness. This evidence concerns the gene MUC5AC and neoplasm.