In PtenL/L:PB-Cre4 mice, most prostatic tumor cells were stained positively for E-cadherin, AR, and CK8 (Fig 6F2, 6F3 and 6F5, respectively) while CK5 positive cells were mainly observed lining the basement membrane areas (Fig 6F6). Here, KRT8 is linked to prostate neoplasm.