In a more recent study in a tau transgenic mouse model for AD, LMTM at doses of 5 and 15 mg/kg/day was found to increase acetylcholine levels in hippocampus, restore choline acetyltransferase activity in basal forebrain, reverse impairment in glutamate release from brain synaptosomes and increase Complex IV activity in brain mitochondria [32]. The gene discussed is MAPT; the disease is Alzheimer disease.