The findings reported in the present study, as well as those reported by others, underscore the importance of considering age at onset, sex, and APOE genotype when interpreting outcomes in AD.9,14,29,32,36 Our future studies will expand on these findings in a longitudinally followed cohort to extend our understanding of the differential treatments39 administered to individuals with HpSp AD, typical AD, and limbic predominant AD. The gene discussed is APOE; the disease is Alzheimer disease.