Moreover, post-mortem studies have revealed a selective loss of PV+ interneurons in people with schizophrenia (Lewis et al., 2012) and overexpression of Neuregulin 1, a leading schizophrenia susceptibility gene, is associated with a reduction of NMDARs on PV+ cells (Kotzadimitriou et al., 2018). The gene discussed is NRG1; the disease is schizophrenia.