Mechanistically, genetic perturbation of CARM1 in the context of leukemia impairs cell-cycle progression, promotes myeloid differentiation, and ultimately induces apoptosis, probably by targeting pathways of proliferation and cell-cycle progression, that is, E2F-, MYC-, and mTOR-regulated processes (Greenblatt et al., 2018). This evidence concerns the gene MYC and leukemia.