MPST and schizophrenia: To determine the functional consequence of excess H2S/polysulfides production under disease conditions, we performed RNA‐seq analysis using Mpst‐KO and Tg mice and detected the DARPP32 and energy metabolism (glycolysis and TCA cycle) systems among the top canonical pathways, dysregulation of which has been documented in schizophrenia (Kunii et al, 2014; Wang et al, 2017; Zuccoli et al, 2017).