IL10 and inflammatory bowel disease: It has been reported that B10 cells are a significant source of IL‐10 in WT mice, and IL‐10 production from regulatory B10 cells ameliorates symptoms and regulates DSS‐induced intestinal injury in IL‐10‐sufficient mice.10 Although IL10−/− mice have more severe colitis than WT mice, IL‐10−/− mice were wildly used in IBD model to investigate the roles of IL‐10 and IL‐10‐producing cells.27, 31 In the current study, we assessed the protective effects of ManLAM‐induced B10 cells.