CD4 and Crohn disease: In Crohn's disease, the major cytokines arise from Th1 and Th17 CD4+ T cell differentiation.23 To elucidate the mechanism for ManLAM‐induced B10 cells alleviating the pathological symptoms and intestinal inflammation in DSS‐induced colitis in mice, we investigate the effects of these B10 cells on CD4+ T cell polarization.