For example, it has been reported that mannose‐binding lectin (MBL) or mannose receptor (MR), which are highly expressed in the intestinal epithelial cells, is required for intestinal homeostasis.32 The impairment in MBL function is associated with IBD.33 Whether ManLAM triggers the MR (or MBL)‐related signalling pathway in B cells to promote the protection cells against IBD should be investigated in future study. This evidence concerns the gene NR3C2 and inflammatory bowel disease.