AKT1 and cancer: Gene Set Enrichment Analysis (GSEA) of the Cancer Genome Atlas (TCGA) Breast invasive carcinoma (BRCA) dataset indicated that low expression of SALL2 correlates with a PI3K/Akt/mTOR signaling signature (Fig 5A; Appendix Fig S4A), suggesting that loss of SALL2 might activate PI3K/Akt/mTOR pathway.