POMC and infection: The side effects of infections, cushingoid features, increased appetite, and weight gain were more commonly noted in the high‐dose prednisolone group than in the low‐dose group, a finding not statistically significant, however.47 Another concern is the adrenal suppression associated with using high‐dose prednisolone;48 however, Kossoff et al. reported fewer adverse effects with prednisolone than ACTH.45 Few participants withdrew from the treatment protocol because of intolerable toxicity.