Treatments vary including antiepileptic drugs, corticotropic hormone, pyridoxine, and a ketogenic diet.8, 9, 10 IS is difficult to control with conventional antiepileptic drugs.11 Vigabatrin is recommended specifically for treatment in IS secondary to tuberous sclerosis complex (TSC).9, 12 The most widely accepted effective treatment for IS not secondary to TSC is hormone therapy.13 It is hypothesized that an excess of corticotrophin‐releasing hormone (CRH) enhances the excitant effects of CRH for numerous neurons. The gene discussed is CRH; the disease is tuberous sclerosis.