Glycyrrhizin, an inhibitor of HMGB1, can bind HMGB1 directly without interfering with other chemokines.15 GL has many biological effects, such as antiviral, anti‐inflammatory, antitumoral, antioxidant and hepatoprotective effects.45 GL can protect against damage caused by drugs, sepsis, ischaemia‐reperfusion and even radiation.18, 46, 47 Our study further confirmed the protective effects of GL against RILI by inhibiting radiation‐induced HMGB1 release and the HMGB1/TLR4 signalling pathway. This evidence concerns the gene TLR4 and Sepsis.