Previous studies have demonstrated that PPARG2, high expression in large intestine, adipose tissue and hematopoietic cells, is known to activate adipocyte genes.29 Recently, PPARγ expression has been described in a variety of human malignancies, including breast cancer, prostate cancer, glioblastoma, non–small cell lung carcinoma, ovarian cancer and pancreatic carcinoma.30 However, the current knowledge about the correlation between PPARG2 and metabolic syndromes in SACC is still missing. This evidence concerns the gene PPARG and breast cancer.