KDR and cancer: Importantly, in breast cancer cells undergoing EMT, an increased expression of fatty acid synthase (FASN) resulted in saturated fatty acids (FAs) accumulation and relocation through activating the EMT inducer VEGF/VEGFR2 signalling.24 The elevated free fatty acid uptake via CD36 was associated with EMT induction in hepatocellular carcinoma.25 These results suggest that EMT may change FFAs to regulate lipid metabolism of cancer cells during cancer progression.