Previous studies indicated that PPARG2 was involved in the regulation of FFAs metabolism of adipocytes and the progression of cancer cells.29, 30 PRRX1 has been shown to target and bind PPARG2 promoter in adipocytes.24 Hence, we first determined whether FFAs have an effect on PRRX1‐induced invasion and migration of SACC cells. Here, PRRX1 is linked to cancer.