In addition, the study of the metastatic MDA‐MB‐231 breast cancer cells showed that hPEBP4 promoted the expression or activity of MMP2, MMP 9 and MMP13 through an increase association of Akt with Src.40 Stimulation of MDA‐MB‐231 with oleic acid induces an increase of MMP9 secretion through a PKC, Src, and EGFR‐dependent pathway.31 Here, we found that tumour‐derived FFAs activated Src and MMP‐9 to induce an increase of Stat5‐DNA to enable tumour migration and invasion, suggesting that FFAs are the novel and clinically relevant metastatic accelerator of SACC. This evidence concerns the gene PEBP4 and neoplasm.