Furthermore, CKD can only be formally diagnosed if low eGFR and/or a high urine albumin:creatinine ratio have been found at two different times, with at least a three month gap2, and 30–40% of patients labelled as CKD stage 3A when the diagnosis is based on only a single eGFR determination move to ‘normal’2. This evidence concerns the gene ALB and chronic kidney disease.