It is known that persistence of high-fat diet or hyper glucose condition in diabetes causes ER stress that induces apoptosis of pancreatic beta cells and insulin resistance.9,12,14,15 Insulin-resistant and hyperglycemic people have reduced HSP70 protein and gene expression.14–16 A recent study reported that GGA administration has induced HSP70 and improved insulin sensitivity and glucose tolerance in monkeys.10 Here, INS is linked to Insulin resistance.