Angiotensin-converting enzyme inhibition81 and angiotensin type 1 receptor blockade80 restored blood pressure in these two mouse models of lipodystrophy, which further supports the contribution of RAS to the development of hypertension in mouse models of lipodystrophy and presents RAS blockade as a potential avenue for the treatment of cardiovascular disease associated with lipodystrophy. This evidence concerns the gene ACE and lipodystrophy.