CAV1 and lipodystrophy: While inherited forms of generalized or partial lipodystrophies are exceedingly rare (1 in 10 million and 1 in 1 million, respectively)2 and mainly caused by autosomal recessive mutations of theAGPAT2, Berardinelli-Seip congenital lipodystrophy 2 (BSCL2), caveolin 1 (CAV1),PTRF genes2–12 or lamin A/C gene13, acquired forms of lipodystrophy, on the other hand, have a relatively higher prevalence with an estimated number of 100,000 patients in the United States.