When comparing with normal ovarian tissues or epithelia, higher TET3 expression is shown in ovarian cancer with different histological grade (Fig. 2b), including grade I (P = 0.0015, logFC = 0.5655), grade II (P < 0.0001, logFC = 0.57) and grade III (P < 0.0001, logFC = 0.6147) This showed that TET3 is up-regulated in serous ovarian cancer especially those with advanced stage (III-IV). This evidence concerns the gene TET3 and ovarian cancer.