KRT7 and nonpapillary renal cell carcinoma: Fourth, RCCs with CCPRCC morphology, diffuse CK7 positivtiy, and with an altered VHL status (mutation, or promoter hypermethylation) do exist; and these tumors can be interpreted as CCRCC with diffuse CK7 positivity, and they can be definitely differentiated from CCPRCCs only by carrying out molecular tests for the VHL status.