Fourth, RCCs with CCPRCC morphology, diffuse CK7 positivtiy, and with an altered VHL status (mutation, or promoter hypermethylation) do exist; and these tumors can be interpreted as CCRCC with diffuse CK7 positivity, and they can be definitely differentiated from CCPRCCs only by carrying out molecular tests for the VHL status. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.