In conclusion, this meta-analysis demonstrated that TERT promoter mutations were likely to present in older patients and were strongly associated with distant metastasis, advanced tumor stage, disease persistence/recurrence, and disease-specific mortality in DTC, and also were associated with male gender, larger tumor size, vascular invasion, extrathyroidal extension, and LNM in PTC, but not in FTC. This evidence concerns the gene TERT and thyroid cancer, nonmedullary, 2.