Even though inhibitors for the production of Ang II such as angiotensin-converting enzyme (ACE) inhibitors and Ang II receptor blockers (ARBs) are currently used to treat hypertension (Food and Drug Administration 2011), a variety of side effects limit the usage particularly in obesity-induced hypertension, which demonstrates higher drug resistance (Setaro and Black 1992). The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.