Besides anti-PD-L1/PD-1 antibodies and anti-CTLA-4 antibodies which have already shown clinical efficacy and had led to FDA approval in the treatment of various solid tumors including HCC [66], other co-inhibitory receptors, such as Lag-3, T cell immunoglobulin mucin-3 (Tim-3), and TIGHT were promising targets to be translated to the clinical development [67]. The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.