STAT3 and colorectal cancer: For instance, the tyrosine kinase Bcr-Abl stimulates STAT3 (Ser727) phosphorylation via JAK/MEK signaling, whereas the Bcr-Abl kinase inhibitor ponatinib suppresses IL-6-stimulated STAT3 phosphorylation in human colorectal cancer (CRC) cells [50, 51].