Osimertinib, a third-generation EGFR-TKI, showed longer median PFS in untreated EGFR-mutated advanced NSCLC patients with BM (osimertinib vs. standard EGFR-TKI: 15.2 vs 9.6 months, p < 0.001) in the phase III FLAURA trial [10]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.