TNF-α levels were significantly decreased (P < 0.001) and IL-10 levels were significantly increased (P < 0.01) when cultured with DFSCs compared to PBMC cultures alone in RA patients, whereas no significant change in cocultures was observed in TNF-α levels in healthy individuals (P ˃ 0.05). The gene discussed is IL10; the disease is rheumatoid arthritis.