CAT and brain ischemia: Asci et al. revealed that pregabalin reduced the level of lipid peroxidation markers, such as thiobarbituric acid reactive substances (TBARS), during cerebral ischemia-reperfusion, and instead increased the activity of glutathione peroxidase (SGH-PX) and CAT enzymes, which are the most important antioxidant enzymes against reactive oxygen substrates [8].