As expected, the native ligand T3 abolished or substantially diminished the transcriptional activity of four THRβ mutants associated with thyroid hormone resistance, V264D, H435L, R438H, and R438W, respectively (Wakasaki et al., 2016, Nomura et al., 1996, Sabet and Pallotta, 2011, Narumi et al., 2010). The gene discussed is THRB; the disease is generalized resistance to thyroid hormone.