Recently, increasing evidence proposes that circRNAs play a crucial role in the initiation and development of cancer.32, 33 Studies have shown that circRNA ZNF292 silencing blocked glioma cell cycle progression through the regulation of Wnt/beta‐catenin signalling pathway, thus suppressed gliomas cells proliferation.34 CircRNAs are also abundantly enriched in vascular endothelial cells, however, the function of circRNAs remains unknown. The gene discussed is CTNNB1; the disease is central nervous system cancer.