USP1 and colorectal cancer: Researchers verified that the expression of some circular isoforms, such as the circRNAs derived from the DCC (deleted in colorectal cancer) gene, diversified across a range of human tissues and was not correlated with its cognate linear mRNA expression.36 Because of the up‐regulation of circ‐USP1 in GECs, we are interested to explore whether the dysregulation of circ‐USP1 was associated with the regulation of BTB function.