The interaction between miRNA and circRNA may competitively affect miRNA‐mediated regulation of their target genes.38, 39, 40 In oral squamous cell carcinoma cells, circ_100290 plays oncogene function by binding with miR‐29b.41 We demonstrated that circ‐USP1 may interact with miR‐194‐5p and function as an endogenous miR‐194‐5p sponge. The gene discussed is USP1; the disease is oral cavity squamous cell carcinoma.