Recently, increasing evidence proposes that circRNAs play a crucial role in the initiation and development of cancer.32, 33 Studies have shown that circRNA ZNF292 silencing blocked glioma cell cycle progression through the regulation of Wnt/beta‐catenin signalling pathway, thus suppressed gliomas cells proliferation.34 CircRNAs are also abundantly enriched in vascular endothelial cells, however, the function of circRNAs remains unknown. This evidence concerns the gene CTNNB1 and cancer.