M2 macrophages, which demonstration anti‐inflammatory properties, are classically defined by the expression of the scavenger (CD163) and mannose (CD204/206) receptors as well as enhanced expression and secretion of immunosuppressive cytokines, such as IL‐10 and transforming growth factor (TGF)‐β1.28 In addition, the expression of arginase 1 (Arg1) counteracts the effects of iNOS from M1 macrophages.25 The kinetics of M2 during sepsis development seems to be a regulatory response to counterbalance M1 activation. This evidence concerns the gene CD163 and Sepsis.