SHBG and polycystic ovary syndrome: The endocrine profile of women with PCOS is characterized by high plasma concentrations of ovarian and adrenal androgens, gonadotropin abnormalities, a relative increase in estrogen levels (especially estrone) derived from the peripheral conversion of androgens, reduced serum levels of sex hormone-binding globulin (SHBG), and often high serum level insulin (INS) [4].