Leelaphiwat et al. [31] did a comparison between the effects of EE 30 mcg/desogestrel 150 mcg plus spironolactone 25 mg/day, versus EE 35 mcg/cyproterone acetate 2 mg, demonstrating significantly decreased acne scores and free androgen index, while increasing SHBG levels. The gene discussed is SHBG; the disease is acne.