Furthermore, when we assessed the relationship between peripheral blood expression of isoforms dysregulated in astrocytes and cognitive decline as measured my Mini Mental State Exam (MMSE), GFAPα and TAU3 transcript levels were positively correlated with cognitive decline, whereas GFAPΑ transcript levels were negatively associated with cognitive decline over a 3–7-year period in participants from the InCHIANTI study of ageing. This evidence concerns the gene GFAP and Mental deterioration.