Moreover, the reduction in the volume of some brain regions, i.e., the prefrontal cortex, the hippocampus, the decrease in dendritic spine density or changes in parvalbumin expression reported in patients in schizophrenia, is also observed in a neurodevelopmental model of schizophrenia based on NMDA receptor dysfunction (du Bois and Huang 2007, Hardingham and Do 2016, Snyder and Gao 2013). This evidence concerns the gene PVALB and schizophrenia.