Because of the potential role of HDAC2 and HDAC5 in the schizophrenia development (Aoyama et al. 2014, Gilbert et al. 2019, Koseki et al. 2012, Schroeder et al. 2017), we analysed their protein levels in untrained CGP-treated adult rats. The gene discussed is HDAC2; the disease is schizophrenia.