In this mini-review, we summarized the recent understanding of the molecular mechanisms of PKM2-associated LncRNAs, including MAFG-AS1, HULC, FEZF1-AS1, LincRNA-p21, MEG3, HOXB-AS3, TP53TG1 and Linc-ROR in cancer metabolism. The gene discussed is FEZF1; the disease is cancer.